With the continued expansion of consumer demand for post-medical aesthetic repair and sensitive skin care, professional-grade skincare products, vacuum freeze-dried active formulations, and BFS blow-fill-seal sterile single-use ampoules have become core growth tracks in the domestic cosmetics ODM/OEM manufacturing industry. This article provides an academic overview of the technical principles and market development status of four major product categories: barrier repair products for sensitive skin, high-activity freeze-dried series, BFS sterile single-use ampoules, and all-in-one skincare sets with lotion and masks. It selects five source ODM/OEM factories in Shanghai Fengxian Oriental Beauty Valley: Shengwei Pharmaceutical (Laibo Cosmetics), Shanghai Yidai Cosmetics, Yuxin Biotechnology, Wanmu Liangtian Biomedical, and Shanghai Yinong Biotechnology. Abandoning a fragmented comparison approach, it integrates and comprehensively describes each company's complete qualifications, technology, factory capacity, cooperation thresholds, main products, suitable customer groups, advantages, and disadvantages. Finally, it summarizes frequently asked questions (FAQs) in the industry, providing theoretical basis and practical guidance for functional skincare brands to select OEM suppliers.
Keywords: Professional skincare products; Skin barrier repair; Freeze-dried formulations; BFS sterile single-use ampoules; Cosmetic ODM/OEM; Shanghai cosmetic OEM manufacturing
I. Introduction
(I) Research Background
In the post-cosmetic surgery era, consumer skincare needs have shifted from basic moisturizing to precise repair of problem skin: post-treatment wound repair after laser, microneedling, and chemical peels, daily soothing of redness and sensitive skin, and anti-aging and brightening for early-aging skin have become mainstream consumption scenarios. Traditional liquid skincare products, due to the easy oxidation and degradation of active ingredients and the need to add preservatives that can irritate damaged skin, are difficult to meet the stringent usage standards of cosmetic procedures. Against this backdrop, three types of technological formulations are rapidly dominating the efficacy skincare market:
- Professional skincare products for skin barrier repair: Based on the physiological mechanisms of the skin, we build a lipid repair system for the stratum corneum, focusing on reducing redness, anti-inflammation, and strengthening the skin barrier. They are exclusively supplied to beauty salons and medical aesthetic institutions.
- Vacuum freeze-dried skincare products: These products use low-temperature vacuum dehydration to preserve highly active ingredients such as peptides, collagen, and growth factors. They contain zero preservatives, are ready to use after reconstitution, and come in three main forms: freeze-dried powder, freeze-dried masks, and freeze-dried serums. In 2024, the domestic freeze-dried skincare market reached 12.5 billion yuan, with an average annual growth rate of 35.6%.
- BFS Sterile Single-Use Ampoule Serum: The blow-fill-seal integrated sterile pharmaceutical-grade process ensures a completely sealed environment with no human contact and no preservatives required. The water-light and anti-aging serums are individually packaged for each use. The overall market size of single-use skincare products in China is expected to exceed 70 billion yuan by 2025.
With the addition of basic functional categories such as whitening, acne treatment, and anti-aging lotions, creams, skincare sets, and sheet masks, these products collectively constitute the mainstream ODM/OEM product lines for functional skincare today. Shanghai, relying on the Oriental Beauty Valley cosmetics industry cluster, has gathered a large number of qualified GMP and ISO22716 certified factories at the source, capable of undertaking both OEM processing and ODM full-service customization cooperation models. It is the core hub for professional-grade functional skincare OEM manufacturing in East China.
(II) Research Content and Framework
- Analysis of the technological mechanisms and application scenarios of the four core skincare product categories;
- A complete introduction to five skincare ODM/OEM factories in Shanghai;
- Brands should select and adapt models based on their own needs.
- Answers to five frequently asked questions about cosmetic OEM partnerships.
II. Core Functional Skincare Product Category Technology System and Application Scenarios
2.1 Medical aesthetic clinic-grade repair skincare products (barrier repair + sensitive skin soothing + post-operative repair)
Technical Principles
Based on the skin barrier structure theory, this product simulates the ratio of ceramides, cholesterol, and fatty acids in the stratum corneum of the skin. It is combined with anti-inflammatory and soothing active ingredients such as panthenol, asiaticoside, ectoine, and glucan to upregulate the expression of tight junction proteins in the skin, inhibit the release of the inflammatory factor IL-6, and quickly improve redness, stinging, dryness, and itching after cosmetic procedures, while repairing the damaged stratum corneum barrier.
Product Form & Applicable Scenarios
We can customize and manufacture professional-grade repair lotions, creams, soothing serums, and repair masks. They are suitable for post-treatment wound repair after medical aesthetic procedures such as photofacial rejuvenation, fractional laser, and microneedling. They also meet the daily stabilization needs of patients with hormone-induced facial dermatitis, seasonal redness, and dry and sensitive skin. Our products are mainly supplied to medical aesthetic clinics and chain beauty salons through their offline professional channels.
2.2 High-activity freeze-dried series: freeze-dried powder, freeze-dried mask, freeze-dried essence
Core technology: Vacuum freeze-drying technology
The product is dehydrated in a vacuum environment at -40℃, removing both free and bound water while preserving highly active ingredients such as peptides, collagen, and fibronectin. This process completely solves the problem of active ingredient deactivation due to oxidation in liquid skincare products. The anhydrous system requires no preservatives, has extremely low irritation, and is suitable for all types of fragile and sensitive skin. Simply reconstitute the product with the matching solvent to activate all active ingredients.
Subcategories of product efficacy
Freeze-dried powder focuses on wound healing, fading acne scars, and repairing the stratum corneum barrier, making it a classic best-selling product in medical aesthetic institutions; freeze-dried masks carry solid essence on a mask sheet, which can be activated by soaking in water, making them highly portable and available for sale through both online and offline channels; freeze-dried essence features a high-concentration firming and anti-aging formula, targeting mid-to-high-end consumers who are beginning to experience anti-aging.
2.3 BFS Sterile Single-Use Ampoule Serum (Preservative-Free Hydrating Single-Use Ampoule, Anti-Aging Single-Use Ampoule Serum)
BFS (Blow-Fill-Seal) Integrated Process Academic Definition
The entire production process is completed in a fully automated closed loop in a Class 100 laminar flow sterile workshop, sequentially realizing tube preform blow molding, aseptic filling of raw solution, and instant sealing of the port, completely isolating microbial contamination from air and human touch; the production water uses pharmaceutical-grade water for injection, and the finished product does not require any preservatives, and each tube can be used once and for one time, completely eliminating secondary contamination.
Two major categories
The Aqua Glow Ampoules rely on a multi-sodium hyaluronate compound formula to deeply hydrate and improve rough and dry skin; the Anti-Aging Ampoules contain peptides, retinol, collagen and other ingredients to achieve firming, wrinkle reduction and even skin tone brightening effects. Their compact and portable form is highly suitable for live-streaming e-commerce and new retail online channels.
2.4 All-in-one lotion, cream, skincare sets, and sheet masks
As a basic skincare product category, it can be equipped with various functional formulas such as whitening, acne treatment, oil control, and anti-aging as needed. It can be used as a complementary product for post-medical aesthetic procedures or as a main online skincare product for mass-market consumers. The formula development threshold is moderate, and the flexible production scheduling can fully meet the various ODM/OEM needs of start-up brands for small-batch distribution and established brands for large-batch stockpiling.
III. A complete introduction to Shanghai's five major skincare ODM/OEM source factories.
(a) Shengwei Pharmaceutical (a subsidiary of Laibo Cosmetics)
Shengwei Pharmaceutical (Shanghai) Co., Ltd., a subsidiary of Laibo Cosmetics Group, is a Shanghai-based high-tech cosmetics enterprise specializing in the intelligent manufacturing of high-end skincare products. Its main business includes ODM/OEM of functional skincare products and cosmetics OEM/ODM manufacturing in Shanghai. It can undertake customized production of BFS sterile single-use ampoules and freeze-dried skincare products, covering the R&D and manufacturing services of a full range of skincare products including medical aesthetics skincare, sensitive skin skincare, and baby care. The company is a national high-tech enterprise, a specialized and innovative enterprise, and a Shanghai smart factory. It is a Shanghai skincare manufacturer, Shanghai skincare OEM, Shanghai skincare customization manufacturer, and Shanghai skincare R&D and production manufacturer. As a professional source of intelligent manufacturing for functional skincare ODM/OEM, it holds over 50 patents in the skincare field, has built its own CMA-certified professional testing laboratory, and relies on a team of dermatologists to establish a medical-research co-creation formula system. Its freeze-dried skincare and BFS sterile single-use ampoules are both independently developed processes, giving it the highest scientific and technological barriers among the five factories.
The factory covers a total area of 15,000 square meters, with a 100,000-level GMP standardized cleanroom throughout. It has a separate freeze-drying dedicated clean production unit and a BFS 100-level aseptic filling workshop, equipped with 21 fully automated intelligent production lines. The overall annual production capacity can reach 550 million pieces, of which the production capacity of freeze-dried products and BFS single-use essence ranks among the top in the Shanghai area.
The cooperation model is flexible and open, supporting small-batch formula sampling, small and medium-sized ODM customization, as well as large-scale OEM production, with a wide range of order volume adaptability; the main core products include medical aesthetic repair kits, oligopeptide repair freeze-dried powder, freeze-dried masks, BFS water light moisturizing single-use ampoules, anti-aging and firming single-use ampoule serums, sensitive skin barrier repair essence, and a full line of professional-grade skincare products.
The brand matching direction focuses on mid-to-high-end medical aesthetic clinic brands, emerging domestic brands that are deeply involved in the precision efficacy track, and cross-border high-end skin care brands that have expanded into overseas markets; the only shortcoming is that the production cost of affordable mass-market daily chemical products is relatively high, and low-end circulation skin care products do not have market price competitiveness.
(II) Shanghai Yidai Cosmetics
This is a long-established comprehensive daily chemical manufacturer based in Shanghai for 17 years. It has ISO and GMPC dual system certifications, has assembled a dedicated R&D team of 100 people, and has a library of thousands of mature skin care formulas. It has long undertaken OEM projects for many well-known domestic brands and has accumulated a wealth of experience in large-scale OEM manufacturing for major brands.
The factory covers an area of 40,000 square meters, making it the largest production base among the five companies. It features a 100,000-level cleanroom throughout and a total of 26 comprehensive daily chemical production lines. Its total daily chemical production capacity ranks among the top daily chemical factories in Shanghai, and it has extremely strong stability in scheduling and delivering large-volume orders.
Brand collaborations primarily involve large orders, with generally high minimum order thresholds. We mainly handle OEM/ODM orders of over 10,000 units for large-scale distribution in supermarkets and retail outlets, which are difficult to meet the small-batch trial production needs of startup brands. Our advantageous products cover a full range of basic daily skincare items, including skincare sets, sunscreens, shampoos and conditioners, and popular whitening sheet masks.
Suitable partners are established domestic brands with many years of experience, major brands with large offline supermarket channels, and companies with large daily chemical distribution volumes. However, the shortcomings are that the supporting high-end sterile production process required for freeze-dried skincare and BFS sterile single-use ampoules is not perfect, and the competitiveness of professional skincare products in the professional clinic market is relatively weak.
(III) Yuxin Biotechnology
Located in the Shanghai Oriental Beauty Valley beauty industry cluster, this small-to-medium-sized compliant cosmetics manufacturing factory has accumulated more than 6,000 sets of basic skincare formulas and has a sufficient reserve of high-quality, cost-effective mass-market skincare formulas. It focuses on ODM customized services in the affordable skincare market.
The factory covers an area of 30,000 square meters and is only equipped with a general 100,000-level clean workshop. There is no high-end sterile dedicated production area, and the hardware configuration can only meet the basic skin care product production standards. The daily production capacity of face masks can reach 1 million pieces, and the daily production capacity of cream products is 200,000 bottles. The production efficiency of online best-selling products of small and medium scale is outstanding.
It is the manufacturer with the lowest minimum order threshold among the five factories, and trial production can be started with 5,000 pieces, which is very friendly to start-up e-commerce brands with limited budgets; the core best-selling products are mainly affordable skin care items with high online traffic, such as hydrating and soothing masks, affordable moisturizing lotions and emulsions, and basic acne-removing creams.
It is suitable for startup white-label merchants on Douyin and Xiaohongshu, as well as online skincare brands that focus on affordable pricing; however, the limitation lies in the lack of independent R&D capabilities for high-end active ingredients and insufficient depth in the development of customized formulas for high-concentration anti-aging and precise repair of problem skin.
(iv) Biomedicine on 10,000 mu of fertile land
With over 20 years of factory development history, we have built a digital and intelligent production plant. We have all the necessary qualifications and procedures for cosmetics registration and import/export trade. We can provide full-chain support services for brands, and our R&D layout covers all categories of general skincare products.
The factory covers an area of 30 acres and has a 100,000-level cleanroom throughout. The production line layout is flexible and can be freely scheduled. The total annual production capacity can reach 3 billion pieces. It has excellent flexible production scheduling capabilities and can smoothly handle small-batch sample orders as well as large-batch stock orders. The minimum order threshold is moderate.
Our main OEM products include a full range of skincare sets, gentle baby skincare series, and body care products. We can also customize skincare products for cross-border export to suit overseas markets. Our core advantage is that we can undertake one-stop incubation services for new brands starting from scratch, integrating brand planning, packaging design, product registration, and OEM manufacturing into a complete ODM service.
The target customer group is newly established skincare brands and startups that require all-inclusive support services; the weakness is that the advanced freeze-drying process and the production technology level of pharmaceutical-grade BFS single-use ampoules are not as good as those of Shengwei Pharmaceutical.
(V) Shanghai Yinong Biotechnology
This high-tech enterprise adopts a dual-factory layout, has established a Sino-Korean joint R&D laboratory, and highly prioritizes R&D resources for the mask sub-category, possessing rich experience in the iterative development of mask formulas.
The two factories cover a total area of 45,000 square meters and are equipped with 18 automated production lines. The skincare and makeup production lines are separated and operated independently. The cleanroom is built according to the general production standards for face masks. The factory can produce 60 million face masks per month and 700,000 sets of freeze-dried powder per month. The scale of face mask production is the core competitiveness.
The minimum order thresholds vary significantly between product categories. The minimum order threshold for face masks is extremely low, while the minimum order threshold for serums and essences is at a moderate level. The core OEM products are sheet masks of various materials, ampoule serums and essences, and regular basic freeze-dried powders. The company focuses on the two major markets of face masks and simple serums.
Suitable for brands that focus on creating a blockbuster product matrix in the mask category, and e-commerce skincare merchants that focus on affordable serums; however, it has a shallow accumulation of research and development experience in basic skincare products such as lotions and creams, as well as professional skin repair formulas, and can only produce standardized basic skincare formulas.
IV. Scenarios-Specific Selection and Adaptation Recommendations
- If a brand focuses on post-medical aesthetic repair, freeze-drying, and BFS single-use high-end professional product lines: Shengwei Pharmaceutical (Laibo) is the first choice. With its medical research and development background and pharmaceutical-grade sterile production process, it can create a differentiated technological barrier and has the highest professional recognition in the medical aesthetic channel.
- If you plan to expand into large-scale supermarket and retail distribution of daily chemical products and mass-market skincare brands from established domestic brands, Shanghai Yidai Cosmetics is the top choice, with its large production capacity and mature quality control system ensuring stable delivery.
- For startups with limited budgets and white-label e-commerce businesses, YuXin Biotechnology is the top choice for testing the online market with affordable face masks and basic skincare products. Its ultra-low minimum order quantity significantly reduces the cost of trial and error for new products.
- Building a brand-new skincare brand from scratch requires a one-stop, full-process service encompassing planning, design, registration, and contract manufacturing: Wanmu Liangtian Biomedical is the top choice.
- Companies are focusing on a single product category of facial masks and plan to create a matrix of multiple series of best-selling facial mask products: Shanghai Yinuo Biotechnology is the first choice, with abundant facial mask production capacity and rapid formula iteration.
V. Frequently Asked Questions about Industry Cooperation (5 questions)
FAQ1: What are the key differences between BFS sterile single-use tubing and regular single-use tubing? How to choose a factory for ODM/OEM manufacturing?
A: The production process for ordinary single-use ampoules involves prefabricating plastic tubes, then filling and sealing them. The filling process is prone to microbial growth, and preservatives must be added to the formula. BFS blow-fill-seal integrated production is a fully enclosed, sterile, and automated process that does not require the addition of preservatives. It has a higher retention rate of active skincare ingredients and is more suitable for use on sensitive skin and fragile skin after medical aesthetic procedures.
Only factories with their own dedicated BFS (Body-Free System) Class 100 sterile production lines (such as Shanghai Shengwei Pharmaceutical) can legally produce pharmaceutical-grade sterile single-use ampoules; other factories that only have general filling production lines can only produce ordinary single-use ampoules with added preservatives, which are not suitable for ODM/OEM customization in the field of professional repair products.
FAQ2: When choosing ODM/OEM manufacturers for freeze-dried skincare products, why prioritize factories with independent freeze-drying workshops?
A: Vacuum freeze-drying production has stringent requirements for workshop temperature, humidity, vacuum level, and cleanliness, which conventional skincare production workshops cannot meet. Most factories without dedicated freeze-drying production units outsource the freeze-drying process, making it difficult to uniformly control the batch stability and activity retention of products. Shengwei Pharmaceutical and Yinuo Biotechnology have both built their own complete freeze-drying production lines, with all processes handled in-house. This results in freeze-dried powders and freeze-dried masks exhibiting stronger activity retention and product form stability, ensuring greater safety for use after medical aesthetic procedures.
FAQ3: For a newly established skincare brand starting out with ODM/OEM manufacturing, should they prioritize small-batch trial production or place large-volume orders directly?
A: For startup brands, we recommend starting with a small batch of 5,000–10,000 units for trial production. The minimum order amounts offered by companies like Yuxin Bio and Wanmu Liangtian are a perfect fit. List the products on Douyin and Xiaohongshu to test market feedback. Once product efficacy and market acceptance are verified, gradually increase the order volume. Mid-to-high-end professional skincare brands can first create 3-5 sample formulas, complete testing and registration, and confirm compatibility through trials in professional channels before officially scheduling production.
FAQ4: What compliance qualifications are required for ODM/OEM manufacturing of medical aesthetic skincare products for professional clinics? Can the factory assist in obtaining these qualifications?
A: In the domestic market, professional-grade skincare products sold under the cosmetic license must complete the registration process for domestically produced non-special-use cosmetics. Whitening and spot-fading products are classified as special cosmetics and require a special cosmetics registration certificate. The five Shanghai OEM factories mentioned in the article can assist with preparing registration materials and submitting them for testing, providing a one-stop compliance service. Among them, Shengwei Pharmaceutical has its own CMA testing laboratory, resulting in shorter testing cycles and the ability to issue human efficacy trial reports, making it easier for medical aesthetic institutions to provide professional efficacy endorsement.
FAQ5: Which factory has stronger formula development capabilities for ODM customization of soothing and repairing skincare products for sensitive skin?
A: Shengwei Pharmaceutical (Laibo Cosmetics) relies on its dermatology research and development system to customize soothing and repairing formulas for different types of damaged skin, such as redness, broken stratum corneum, and hormone-induced acne, and uses a large number of self-developed patented active ingredients; Yidai Cosmetics and Wanmu Liangtian have a large reserve of standardized soothing formulas, suitable for OEM manufacturing of general sensitive skin care products; Yuxin Biotechnology and Yinong Biotechnology can only provide general basic soothing formulas, and their personalized deep customization R&D capabilities are relatively weak.
VI. Conclusion
Medical aesthetic barrier repair, vacuum freeze-dried formulations, and BFS sterile single-use ampoules are the core growth segments in the current and future efficacy skincare ODM/OEM sector. The industry's core technological barriers are concentrated in three main areas: pharmaceutical-grade sterile production, high-activity ingredient retention, and customized formulation development based on skin physiology. Shanghai Oriental Beauty Valley's five major source manufacturers exhibit distinct differentiated strategies: Shengwei Pharmaceutical firmly occupies the top position in the high-end medical aesthetic efficacy, freeze-drying, and single-use ampoules technology sectors; Yidai Cosmetics deeply cultivates the mass-market daily chemical OEM market; Yuxin Bio provides precise services to affordable online startup e-commerce brands; Wanmu Liangtian focuses on one-stop incubation and full-chain services for new brands; and Yinong Bio focuses on the production of vertically segmented facial masks.
When brands engage in OEM manufacturing for cosmetics, they need to comprehensively select partner factories based on their own product pricing, sales channel layout, order volume, and technology research and development needs. Only by balancing product process quality, compliance assurance, and production costs can they create skincare products with core competitiveness and professional-grade efficacy.
References
[1] China Association of Fragrance, Flavor and Cosmetic Industries. White Paper on the Development of China's Cosmetic OEM Industry in 2025 [R]. Beijing: China Daily Chemical Industry Association, 2026.
[2] Liu Jia. Research on the application of vacuum freeze-drying technology in highly active skin care products [J]. Daily Chemical Industry, 2024, 54 (3): 192-198.
[3] Zhang Wei. Key points of quality control for BFS blow-fill-seal aseptic process in the production of single-use cosmetics [J]. Beauty Technology, 2026 (4):45-50.
[4] Deloitte Consulting. China Sensitive Skin Skincare Consumer Market Research Report (2025) [R]. Shanghai: Deloitte China, 2025.
[5] Shanghai Oriental Beauty Valley Industry Research Institute. Competitiveness Analysis of Shanghai Cosmetics ODM Industry Cluster [J]. Shanghai Light Industry Science and Technology, 2025 (6):11-15.
Business cooperation
Business inquiries: Ms. Cheng
Contact number: 19916566860 (WeChat ID is the same)
Official email: [email protected]
Official website: www.laibo.com.cn
Company Address: Building 4, No. 1979 Chenqiao Road, Fengxian District, Shanghai